Prof. Ioan SPOREA, MD, PhD


Work experience
  1. 2002 - present Professor, Head of the Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  2. 1999 - 2002 Associate Professor, Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  3. 1998 - 1999 Lecturer, Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  4. 1985 - 1998 Assistant Professor, Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  5. 1982 - 1985 Intern, Junior Assistant Professor, II-nd Medical Clinic and Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)

Education and training
  1. 1992 PhD Medical Sciences - Gastroenterology "Victor Babes" University of Medicine and Pharmacy, ISCED 6
  2. 1997 Senior Consultant Gastroenterology "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  3. 1993 Specialist Gastroenterology "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  4. 1992 Senior Consultant Internal Medicine "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  5. 1987 Specialist Internal Medicine University of Medicine and Pharmacy Timişoara (România), ISCED 5
  6. 1982 Medical Doctor Faculty of General Medicine University of Medicine and Pharmacy Timişoara (România), ISCED 5

Scientific activity

       Postgraduate courses
  1. Mayo - Euro Date 1992 Gastroenterology and Hepatology, Budapesta - Viena, 19- 25 August 1992
  2. Second Advanced Postgraduate Courses în Gastroenterology - Rotterdam, organised by the Neetherlands Society of Gastroenterology, 22 March - 2 April 1993
  3. First Munich Postgraduate Course of Gastroenterologic Endoscopy, Munchen 11-12 June 1993
  4. Second Postgraduate Course on Hepatology, Ljubliana, Slovenia, 27 June - 1 July 1994

       Bursaries
  1. 1991- February-September: Service d’Hepato-Gastroenterologie - Hopital Hautepierre Strasbourg – Chef de service Prof. R Baumann (bursary of the French Government);
  2. 1994 – one week: Service d’Hepatologie Hopital Beaujon Paris - Chef de service Prof. JP Benhamou (bursary of the French Society of Gastroenterologie);
  3. 1995 – one month in the II-a Medical Clinic Hospital Rechts Isaar din Munchen – Head of Department Prof. M Classen;
  4. 1996 - one week: Service d’Echoendoscopie Dr. L Palazzo Paris (bursary of the French Society of Gastroenterologie).
  5. 1997 - two weeks in the Gastroenterology Clincs of Arnheim, Amsterdam, Rotterdam the Neetherlands.
  6. 1998 - three weeks the Liver Transplant Program of Baylor University Medical Center, Dallas Texas, USA
  7. 2000 - two weeks the Liver Transplant Program of Baylor University Medical Center, Dallas Texas, USA

       Member of:
  1. European Federation of Societies for Ultrasound in Medicine and Biology - member of the Executive Board (1999-2002), 1999 - 2005 member of the Educational Committee of EFSUMB, 2007-2011 Honorary treasurer
  2. Romanian Society of Ultrasound in Medicine and Biology (President 2006-2010)
  3. The Romanian Society of Gastroenterology and Hepatology (1994), vice-president since 2001, President since 2013
  4. Romanian Society of Hepatology
  5. European Association of Gastroenterology and Digestive Endoscopy (EAGE) - 1989
  6. European Association for the Study of the Liver (EASL) - 1993
  7. Italian Society of Gastroenterology, corresponding member
  8. American Gastroenterological Association (2005)
  9. Fellow of the European Board of Gastroenterology (Gastroenterology Section of The European Union of Medical Sciences) (2006)
  10. Editorial Board of: European J Ultrasound, JGLD, Medical Ultrasound
  11. Member of the Faculty of UEGW Ultrasound Learning Centre since 2003

       Awards:
  1. ”Young Investigator Award” – Yokohama 1996 – The 10-th Asian-Pacific Congress of Gastroenterology
  2. The Great Prize of the Romanian Society of Ultrasound in Medicine and Biology – “Gheorghe Badea” 1999 – “For Outstanding Scientific and Editorial Activity in 1999”
  3. The “Gheorghe Badea” Award of the Romanian Society of Ultrasound in Medicine and Biology in 2002
  4. The “Gheorghe Badea” Award of the Romanian Society of Ultrasound in Medicine and Biology in 2006
  5. The “Gheorghe Badea” Award of the Romanian Society of Ultrasound in Medicine and Biology in 2013
  6. The “Gheorghe Jovin” Award of the Romanian Society of Ultrasound in Medicine and Biology in 2014
  7. Prize of excellence in Gastroenterology Medic.ro – Gastroenterology, IIIrd edition, 2006

       Publications:
  1. Author and co-author of 252 original papers published in medical journals, 117 of them in ISI journals
  2. Author and co-author of more than 1500 studies presented at and published in the abstract books of various scientific medical meetings
  3. First author of 12 medical books. Co-author of 14 medical books
  4. First author of 16 medical compact disks (Ultrasound and Endoscopy)
  5. First author of ECB Chapter 03 - Estimation of liver stiffness using ultrasound waves" from the EFSUMB European Course Book available on line at: http://www.efsumb.org/ecb/ecb-ch03-stiffnessliver.pdf
  6. First author in ”Hepatic Elastography Using Ultrasound Waves”, Ioan Sporea, Roxana Șirli. Bentham Science Publishers 2012. eISBN: 978-1-60805-463-3, 2012; ISBN: 978-1-60805-557-9.

       Grants:
  1. Local coordinator of the National CEEX Grant nr. 1/2005: “Molecular basis of colorectal cancer: from prevention to treatment”, as well as to the
  2. Local coordinator National CEEX Grant nr. 68/2006 “Optimising the early diagnosis and treatment of upper digestive tract cancer in the context of chromodiagnosis and magnification endoscopy”
  3. Local coordinator in Deployment of a telemedicine system between university gastroenterology centres of Szeged and Timisoara for education and training of professionals. Cross-border project HURO/1001/140/2.3.1

Main publications
  1. Pegylated-interferon alpha 2a treatment for chronic hepatitis C in patients on chronic haemodialysis. Sporea I, Popescu A, Șirli R, Golea O, Totolici C, Danila M, Vernic C.; World J Gastroenterol 2006 Jul 14; 12(26):4191-4
  2. Comparative study concerning the efficacy of Peg-IFN alpha-2a versus Peg-IFN alpha-2b on the early virological response (EVR) in patients with chronic viral C hepatitis. Sporea I, Danila M, Șirli R, Popescu A, Laza A, Bădițoiu L; J Gastrointestin Liver Dis 2006 Jun; 15(2):125-30
  3. A survey on the Practice of Gastroenterology in Romania. Sporea I, Popescu A, Șirli R, Enăchescu V, Deleanu A, Miuţescu E; J Gastrointestin Liver Dis 2006; 15(3):313-316
  4. Efficacy, Tolerability and Predictive Factors for Early and Sustained Virologic Response in Patients Treated with Weight-Based Dosing Regimen of PegIFN alpha-2b and Ribavirin in Real-Life Healthcare Setting Gheorghe L, Iacob S, Sporea I, Grigorescu M, Șirli R, Damian D, Gheorghe C, Iacob R.; J Gastrointestin Liver Dis 2007 March; 16(1): 23-9
  5. The quality of the fragment obtained by liver biopsy for staging chronic hepatitis. Sporea I, Şirli R, Popescu A, Cornianu C, Manciu C, Focşa M.; J Gastrointestin Liver Dis 2007; 16( 3), p.263-266
  6. How to improve the performances in diagnostic colonoscopy? Sporea I, Popescu A, Vernic C, Şirli R.; J Gastrointestin Liver Dis 2007; 16(4), p.363-368
  7. Comparison of the liver stiffness measurement by transient elastography with the liver biopsy. Sporea I, Şirli R, Deleanu A, Tudora A, Curescu M, Cornianu M, Lazar D.; World J Gastroenterol Nov 2008; 14(42):6513-7
  8. Why, who and how should perform liver biopsy in chronic liver diseases. Sporea I, Popescu A, Şirli R.; World J Gastroenterol Jun 2008; 14(21):3396-402
  9. Liver Stiffness Measurement by Transient Elastography in Clinical Practice. Sporea I, Şirli R, Deleanu A, Popescu A, Cornianu M.; J Gastrointestin Liver Dis 2008;17(4): 395-399
  10. Immunohistochemical evaluation of the tumor neoangiogenesis as a prognostic factor for gastric cancers. Lazăr D, Tăban S, Raica M, Sporea I, Cornianu M, Goldiş A, Vernic C.; Rom J Morphol Embryol. 2008;49(2):137-48.
  11. Immunohistochemical expression of the cyclooxygenase-2 (COX-2) in gastric cancer. The correlations with the tumor angiogenesis and patients' survival. Lazăr D, Tăban S, Ardeleanu C, Simionescu C, Sporea I, Cornianu M, Vernic C.; Rom J Morphol Embryol. 2008;49(3):371-9.
  12. The immunohistochemical expression of E-cadherin in gastric cancer; correlations with clinicopathological factors and patients' survival. Lazăr D, Tăban S, Ardeleanu C, Dema A, Sporea I, Cornianu M, Lazăr E, Vernic C.; Rom J Morphol Embryol. 2008;49(4):459-67.
  13. Gastric cancer: the correlation between the clinicopathological factors and patients' survival (I). Lazăr D, Tăban S, Dema A, Cornianu M, Goldiş A, Raţiu I, Sporea I.; Rom J Morphol Embryol. 2009;50(1):41-50.
  14. HCV genotype 1 is almost exclusively present in Romanian patients with chronic hepatitis C. Grigorescu M; Romanian Society of Gastroenterology and Hepatology; J Gastrointestin Liver Dis. 2009 Mar;18(1):45-50.
  15. Mutant HFE genotype leads to significant iron overload in patients with liver diseases from western Romania. Neghina AM, Anghel A, Sporea I, Popescu A, Neghina R, Collins A, Thorstensen K.; J Appl Genet. 2009;50(2):173-6.
  16. Gastric cancer: correlation between clinicopathological factors and survival of patients. II. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C.; Rom J Morphol Embryol. 2009;50(2):185-94.
  17. Gastric cancer: correlation between clinicopathological factors and survival of patients (III). Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C.; Rom J Morphol Embryol. 2009;50(3):369-79
  18. Efficacy and safety of peginterferon alpha-2a (40KD) in HBeAg-positive chronic hepatitis B patients. Caruntu FA, Streinu-Cercel A, Gheorghe LS, Grigorescu M, Sporea I, Stanciu C, Andronescu D, Voinea F, Diculescu M, Oproiu A, Voiosu R; J Gastrointestin Liver Dis. 2009 Dec;18(4):425-31
  19. High Sustained Virological Response Rate to Combination Therapy in Genotype 1 Patients with Histologically Mild Hepatitis C. Gheorghe L, Iacob S, Grigorescu M, Sporea I, Șirli R, Damian D, Gheorghe G, Iacob R.; J Gastrointestin Liver Dis 2009; 18(1): 51-56.
  20. The value of transabdominal ultrasound for assessment of the severity of liver steatosis as compared to liver biopsy. Sporea I, Şirli R, Başa E, Cornianu M, Popescu A, Dănilă M, Focșa M.; Central European Journal of Medicine, 2009:4 (4): 490-495.
  21. Percutaneous Ethanol Injection Therapy in the Treatment of Hepatocarcinoma - Results Obtained from a Series of 88 Cases Dănilă M, Sporea I, Şirli R, Popescu A.; J Gastrointestin Liver Dis 2009; 18 3, 317-322.
  22. Transient elastographic evaluation of subjects without known hepatic pathology, does age change the liver stiffness? Şirli R, Sporea I, Tudora A, Deleanu A, Popescu A.; J Gastrointestin Liver Dis 2009; 18(1): 57-61.
  23. A Comparative Study of Non-Invasive Methods for Fibrosis Assessment in Chronic HCV Infection. Şirli R, Sporea I, Bota S, Popescu A, Cornianu M.; Hepatitis Monthly 2010; 10(2): 88-94.
  24. The immunohistochemical expression of the p53-protein in gastric carcinomas. Correlation with clinicopathological factors and survival of patients. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Raţiu I, Vernic C.; Rom J Morphol Embryol. 2010;51(2): 249-57.
  25. Colonoscopy and sedation in Romania: early experience using a balanced propofol regimen. Sporea I, Popescu A, Sandesc D, Bedreag O, Asai R, Șirli R, Vernic C, Nicolita D, Martie A; J Gastrointestin Liver Dis. 2010 Mar;19(1): 27-30.
  26. Outcome of antiviral treatment in patients with chronic genotype 1 HCV hepatitis. A retrospective study in 507 patients. Sporea I, Șirli R, Curescu M, Gheorghe L, Popescu A, Bota S, Iacob S.; J Gastrointestin Liver Dis. 2010 Sep;19(3): 261-4.
  27. Liver stiffness measurements in patients with HBV vs HCV chronic hepatitis: a comparative study Sporea I, Șirli R, Deleanu A, Tudora A, Popescu A, Curescu M, Bota S.; World J Gastroenterol. 2010 Oct 14;16(38): 4832-7.
  28. How useful is contrast enhanced ultrasonography for the characterization of focal liver lesions? Sporea I, Șirli R, Martie A, Popescu A, Danila M.; J Gastrointestin Liver Dis. 2010 Dec;19(4): 393-8.
  29. How to improve the quality of the tissue sample obtained by percutaneous liver biopsy. Sporea I, Popescu A, Şirli R.; Central European Journal Of Medicine 2010; 6(1): 103-106.
  30. Ki-67 expression in gastric cancer. Results from a prospective study with long-term follow-up. Lazăr D, Tăban S, Sporea I, Dema A, Cornianu M, Lazăr E, Goldiş A, Vernic C.; Rom J Morphol Embryol. 2010;51(4): 655-61.
  31. Ultrasound examination of normal gall bladder and biliary system. Popescu A, Sporea I.; Med Ultrason. 2010 Jun;12(2):150-2.
  32. Ultrasound examination of the normal gastrointestinal tract. Sporea I, Popescu A.; Med Ultrason. 2010 Dec;12(4): 349-52.
  33. Ultrasound examination of the normal pancreas. Șirli R, Sporea I.; Med Ultrason 2010: 12(1): 62-65.
  34. Contrast Enhanced Ultrasound in focal liver lesions – a cost efficiency study. Şirli R, Sporea I, Martie A, Popescu A, Dănilă M.; Med Ultrason 2010, 12 (4), 280-285
  35. Acoustic Radiation Force Impulse (ARFI) – a new modality for the evaluation of liver fibrosis. Sporea I, Şirli R, Popescu A, Danilă M.; Med Ultrason 2010: 12(1): 26-31
  36. The role of contrast enhanced ultrasound (CEUS) in the assessment of liver nodules in patients with cirrhosis. Danila M, Sporea I, Șirli R, Popescu A, Sendroiu M, Martie A.; Med Ultrason 2010: 12(2): 145-149
  37. Spleen assessment by Acoustic radiation Force Impulse Elastography (ARFI) for prediction of liver cirrhosis and portal hypertension Bota S, Sporea I, Șirli R, Popescu A, Danila M, Sendroiu M, Focsa M.; Med Ultrason 2010; 12 (3): 213-215
  38. Contrast enhanced ultrasound (CEUS) in the evaluation of liver metastases. Danila M, Popescu A, Șirli R, Sporea I, Martie A, Sendroiu M.; Med Ultrason 2010; 12 (3): 233-237
  39. Does the antiviral therapy of patients with chronic hepatitis exert nephrotoxic effects? Gluhovschi C, Gadalean F, Kaycsa A, Curescu M, Sporea I, Gluhovschi G, Petrica L, Velciov S, Bozdog G, Bob F, Vernic C, Cioca D.; Immunopharmacol Immunotoxicol. 2011 Dec;33(4): 744-50.
  40. Clinical penetrance of C282Y homozygous HFE hemochromatosis in a western Romanian population. Neghina AM, Anghel A, Sporea I, Popescu A.; J Gastrointestin Liver Dis. 2011 Mar;20(1): 100-1.
  41. Aspartate aminotransferase to platelet ratio index for the assessment of liver fibrosis severity in patients with chronic hepatitis. Șirli R, Sporea I.; Hepat Mon. 2011;11(7): 560-561
  42. The mean values of liver stiffness assessed by Acoustic Radiation Force Impulse elastography in normal subjects. Popescu A, Sporea I, Șirli R, Bota S, Focsa M, Danila M, Nicolita D, Martie A, Sendroiu M, Juchis A.; Med Ultrason. 2011 Mar;13(1):33-7
  43. Contrast Enhanced Ultrasound for the characterization of focal liver lesions Sporea I, Badea R, Martie A, Șirli R, Socaciu M, Popescu A, Danila M.; Med Ultrason. 2011 Mar;13(1):38-44
  44. The value of contrast enhanced ultrasound in the evaluation of the nature of portal vein thrombosis. Dănilă M, Sporea I, Popescu A, Șirli R, Sendroiu M.; Med Ultrason. 2011 Jun;13(2):102-7
  45. Contrast enhanced ultrasound for the characterization of hepatocellular carcinoma. Martie A, Sporea I, Popescu A, Șirli R, Dănilă M, Serban C, Ardelean M, Bota S, Sendroiu M, Chisevescu D.; Med Ultrason. 2011 Jun;13(2):108-13
  46. Factors that influence the correlation of Acoustic Radiation Force Impulse (ARFI), elastography with liver fibrosis. Bota S, Sporea I, Șirli R, Popescu A, Danila M, Sendroiu M.; Med Ultrason. 2011 Jun;13(2):135-40
  47. The influence of liver residual mass on the values of Acoustic Radiation Force Impulse Elastography (ARFI) in cirrhotic patients. Bota S, Sporea I, Șirli R, Popescu A, Dănilă M, Sendroiu M.; Med Ultrason. 2011 Sep;13(3):195-9
  48. Contrast enhanced ultrasound for the diagnosis of liver hemangiomas in clinical practice Șirli R, Sporea I, Popescu A, Dănilă M, Martie A, Bota S, Jurchis A, Sendroiu M.; Med Ultrason. 2011 Jun;13(2):95-101
  49. What Did We Learn from the First 3,459 Cases of Liver Stiffness Measurement by Transient Elastography (FibroScan(R))? Sporea I, Șirli RL, Deleanu A, Rațiu I, Tudora A, Dan I, Popescu A.; Ultraschall Med. 2011 Feb;32(1):40-45.
  50. Acoustic Radiation Force Impulse Elastography as Compared to Transient Elastography and Liver Biopsy in Patients with Chronic Hepatopathies. Sporea I, Șirli RL, Deleanu A, Popescu A, Focsa M, Danila M, Tudora A.; Ultraschall Med. 2011;32 Suppl 1:S46-52
  51. Thyroid Stiffness Assessment by Acoustic Radiation Force Impulse Elastography (ARFI). Sporea I, Vlad M, Bota S, Șirli RL, Popescu A, Danila M, Sendroiu M, Zosin I.; Ultraschall Med. 2011 Jun;32(3):281-5
  52. Value of transient elastography for the prediction of variceal bleeding. Sporea I, Raţiu I, Șirli R, Popescu A, Bota S.; World J Gastroenterol. 2011 May 7;17(17):2206-10
  53. How efficient is acoustic radiation force impulse elastography for the evaluation of liver stiffness?. Sporea I, Badea R, Șirli R, Lupsor M, Popescu A, Danila M, Focsa M, Deleanu A; Hepat Mon. 2011;11(7):532-8
  54. A new scoring system for prediction of fibrosis in chronic hepatitis C. Bota S, Șirli R, Sporea I, Focsa M, Popescu A, Danila M, Strain M, Sendroiu M, Deleanu A, Dan I.; Hepat Mon. 2011;11(7):548-5
  55. Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography.Fibroscan in inactive HBsAg carriers Sporea I, Nicolita D, Șirli R, Deleanu A, Tudora A, Bota S; Hepat Mon. 2011;11(3):182-185
  56. Is it better to use two elastographic methods for liver fibrosis assessment? Sporea I, Şirli R, Popescu A, Bota S, Badea R, Lupşor M, Focşa M, Dănilă M.; World J Gastroenterol 2011; 17(33): 3824-3829.
  57. Response to standard of care antiviral treatment in patients with HCV liver cirrhosis - a systematic review. Bota S, Sporea I, Popescu A, Șirli R, Neghina AM, Danila M, Strain M.; J Gastrointestin Liver Dis. 2011 Sep;20(3):293-8
  58. Authors' reply. Bota S, Sporea I, Șirli R.; J Gastrointestin Liver Dis. 2011 Dec;20(4):445-6
  59. The Correlation of Il28B Genotype With Sustained Virologic Response In Romanian patients With Chronic Hepatitis C. Sporea I, Popescu A, Curescu M, Șirli R, Dan I, Goldis A, Gradinaru O, Ardelean M, Danila M, Bota S, Deleanu A.; Hepat Mon. 2011 Dec;11(12):975-9.
  60. Weight-based dosing regimen of peg-interferon α-2b for chronic hepatitis delta: a multicenter Romanian trial Gheorghe L, Iacob S, Simionov I, Vadan R, Constantinescu I, Caruntu F, Sporea I, Grigorescu M.; J Gastrointestin Liver Dis. 2011 Dec;20(4):377-82.
  61. Intra- and Interoperator Reproducibility of Acoustic Radiation Force Impulse (ARFI) Elastography-Preliminary Results. Bota S, Sporea I, Șirli R, Popescu A, Danila M, Costachescu D.; Ultrasound Med Biol. 2012 Jul;38(7):1103-8
  62. Comparative Study Concerning the Value of Acoustic Radiation Force Impulse Elastography (ARFI) in Comparison with Transient Elastography (TE) for the Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B and C. Sporea I, Șirli R, Bota S, Popescu A, Sendroiu M, Jurchis A.; Ultrasound Med Biol. 2012 Aug;38(8):1310-6
  63. Can ARFI elastography predict the presence of significant esophageal varices in newly diagnosed cirrhotic patients? Bota S, Sporea I, Șirli R, Focsa M, Popescu A, Danila M, Strain M.; Ann Hepatol. 2012 Jul;11(4):519-25.
  64. Does the size of the needle influence the number of portal tracts obtained through percutaneous liver biopsy? Sporea I, Gherhardt D, Popescu A, Șirli R, Cornianu M, Herman D, Bota S.; Ann Hepatol. 2012 Sep;11(5):691-5
  65. Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study. Sporea I, Bota S, Peck-Radosavljevic M, Șirli R, Tanaka H, Iijima H, Badea R, Lupsor M, Fierbinteanu-Braticevici C, Petrisor A, Saito H, Ebinuma H, Friedrich-Rust M, Sarrazin C, Takahashi H, Ono N, Piscaglia F, Borghi A, D'Onofrio M, Gallotti A, Ferlitsch A, Popescu A, Danila M.; Eur J Radiol. 2012 Dec;81(12):4112-8
  66. Hepatic Elastography for the Assessment of Liver Fibrosis - Present and Future. Sporea I, Șirli R.; Ultraschall Med. 2012 Dec;33(6):550-558
  67. Quiz. Cystic tumor of the Liver. Șirli R, Sporea I, Jurchis A.; Med Ultrason. 2012 Mar;14(1):78-9
  68. Answer QUIZ vol. 14, no.1. Cystic tumor of the liver. Șirli R, Sporea I, Jurchis A.; Med Ultrason. 2012 Jun;14(2):169-70
  69. Liver elastography for the diagnosis of portal hypertension in patients with liver cirrhosis. Șirli R, Sporea I, Bota S, Ratiu I.; Med Ultrason. 2012 Sep;14(3):225-30
  70. Contrast Enhanced Ultrasound for the evaluation of focal liver lesions in daily practice. A multicentre study. Sporea I, Badea R, Martie A, Dumitru E, Ioanitescu S, Șirli R, Socaciu M, Popescu A, Dănilă M, Voiculescu M.; Med Ultrason. 2012 Jun;14(2):95-100
  71. The Contribution of Contrast Enhanced Ultrasound for the characterization of benign liver lesions in clinical practice - a monocentric experience. Martie A, Bota S, Sporea I, Șirli R, Popescu A, Danila M.; Med Ultrason. 2012 Dec;14(4):283-7
  72. Performance of Acoustic Radiation Force Impulse imaging for the staging of liver fibrosis: a pooled meta-analysis. Friedrich-Rust M, Nierhoff J, Lupsor M, Sporea I, Fierbinteanu-Braticevici C, Strobel D, Takahashi H, Yoneda M, Suda T, Zeuzem S, Herrmann E.; J Viral Hepat. 2012 Feb;19(2):e212-9.
  73. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Loguercio C, Andreone P, Brisc C, Brisc MC, Bugianesi E, Chiaramonte M, Cursaro C, Danila M, de Sio I, Floreani A, Freni MA, Grieco A, Groppo M, Lazzari R, Lobello S, Lorefice E, Margotti M, Miele L, Milani S, Okolicsanyi L, Palasciano G, Portincasa P, Saltarelli P, Smedile A, Somalvico F, Spadaro A, Sporea I, Sorrentino P, Vecchione R, Tuccillo C, Del Vecchio Blanco C, Federico A.; Free Radic Biol Med. 2012 May 1;52(9):1658-65.
  74. WGO digestive oncology task force: validation of hepatogastroenterologist practice in oncology. Valean S, Mulder CJ, Pascu O, Stanciu C, Diculescu MM, Tantau M, Sporea I, Ciulean TE, Mircea PA.; J Gastrointestin Liver Dis. 2012 Sep;21(3):239-42
  75. "Quo vadis" liver biopsy? A multi-centre Romanian study regarding the number of liver biopsies performed for chronic viral hepatitis. Sporea I, Popescu A, Gheorghe L, Cijevschi Prelipcean C, Spârchez Z, Voiosu R; J Gastrointestin Liver Dis. 2012 Sep;21(3):326.
  76. Shear wave elastography. Sporea I, Lie I.; Ultraschall Med. 2012 Aug;33(4):393-4.
  77. Ferric carboxymaltose prevents recurrence of anemia in patients with inflammatory bowel disease. Evstatiev R, Alexeeva O, Bokemeyer B, Chopey I, Felder M, Gudehus M, Iqbal T, Khalif I, Marteau P, Stein J, Gasche C; FERGI Study Group.; Clin Gastroenterol Hepatol. 2013 Mar;11(3):269-77.
  78. Factors which influence the accuracy of acoustic radiation force impulse (ARFI) elastography for the diagnosis of liver fibrosis in patients with chronic hepatitis C. Bota S, Sporea I, Sirli R, Popescu A, Jurchis A.; Ultrasound Med Biol. 2013 Mar;39(3):407-12
  79. The influence of food intake on liver stiffness values assessed by acoustic radiation force impulse elastography-preliminary results. Popescu A, Bota S, Sporea I, Sirli R, Danila M, Racean S, Suseanu D, Gradinaru O, Ivascu Siegfried C.; Ultrasound Med Biol. 2013 Apr;39(4):579-84
  80. Technical performance of colonoscopy - multicenter study in university and non-university centers of Romania. Sporea I, Popescu A, Diculescu M, Stoica V, Constantinescu G, Prelipcean CC, Seicean A, Pascu O, Jinga M, Tudor N, Voiosu R, Dobru D, Săftoiu A, Vălean S, Miuţescu E, Bancu L, Băţagă S, Dumitraşcu D, Brisc C, Frăţilă O, Raţiu I, Pienar L, Şirli R, Miuţescu B.; Chirurgia (Bucur). 2013 Jan-Feb;108(1):86-90.
  81. The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: a retrospective multicentre study. Bota S, Sporea I, Peck-Radosavljevic M, Sirli R, Tanaka H, Iijima H, Saito H, Ebinuma H, Lupsor M, Badea R, Fierbinteanu-Braticevici C, Petrisor A, Friedrich-Rust M, Sarrazin C, Takahashi H, Ono N, Piscaglia F, Marinelli S, D'Onofrio M, Gallotti A, Salzl P, Popescu A, Danila M; Dig Liver Dis. 2013 Sep;45(9):762-8.
  82. Role of interleukin-28B polymorphism as a predictor of sustained virological response in patients with chronic hepatitis C treated with triple therapy: a systematic review and meta-analysis. Bota S, Sporea I, Şirli R, Neghină AM, Popescu A, Străin M.; Clin Drug Investig. 2013 May;33(5):325-31.
  83. To scope or to test for colorectal cancer screening? Sporea I, Popescu A.; J Gastrointestin Liver Dis. 2013 Mar;22(1):11-2
  84. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 1: Basic principles and technology. Bamber J, Cosgrove D, Dietrich CF, Fromageau J, Bojunga J, Calliada F, Cantisani V, Correas JM, D'Onofrio M, Drakonaki EE, Fink M, Friedrich-Rust M, Gilja OH, Havre RF, Jenssen C, Klauser AS, Ohlinger R, Saftoiu A, Schaefer F, Sporea I, Piscaglia F.; Ultraschall Med. 2013 Apr;34(2):169-84.
  85. Factors influencing reliability of liver stiffness measurements using transient elastography (M-probe)-monocentric experience. Sirli R, Sporea I, Bota S, Jurchiş A.; Eur J Radiol. 2013 Aug;82(8):e313-6.
  86. EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. Part 2: Clinical applications. Cosgrove D, Piscaglia F, Bamber J, Bojunga J, Correas JM, Gilja OH, Klauser AS,Sporea I, Calliada F, Cantisani V, D'Onofrio M, Drakonaki EE, Fink M, Friedrich-Rust M, Fromageau J, Havre RF, Jenssen C, Ohlinger R, Săftoiu A, Schaefer F, Dietrich CF; EFSUMB.; Ultraschall Med. 2013 Jun;34(3):238-53.
  87. Can transient elastography be a reliable method for assessing liver fibrosis in non alcoholic steatohepatitis (NASH)? Sporea I, Jurchiş A, Şirli R, Bota S, Sendroiu M.; Med Ultrason. 2013 Jun;15(2):106-10
  88. Are different cut-off values of liver stiffness assessed by transient elastography according to the etiology of liver cirrhosis for predicting significant esophageal varices? Sporea I, Raţiu I, Bota S, Şirli R, Jurchiş A.; Med Ultrason. 2013 Jun;15(2):111-5.
  89. Liver stiffness measurements by means of supersonic shear imaging in patients without known liver pathology. Sirli R, Bota S, Sporea I, Jurchis A, Popescu A, Gradinaru-Tascău O, Szilaski M.; Ultrasound Med Biol. 2013 Aug;39(8):1362-7
  90. Time for individualized colonoscopy bowel-prep regimens? A randomized controlled trial comparing sodium picosulphate and magnesium citrate versus 4-liter split-dose polyethylene glycol. Voiosu T, Ratiu I, Voiosu A, Iordache T, Schipor A, Baicus C, Sporea I, Voiosu R.; J Gastrointestin Liver Dis. 2013 Jun;22(2):129-34.
  91. Is There any Difference Between the Glomerular Filtration Rate of Patients With Chronic Hepatitis B and C and Patients With Cirrhosis? Gluhovschi C, Velciov S, Buzas R, Petrica L, Bozdog G, Gadalean F, Gluhovschi A, Balgradean C, Vernic C, Sporea I.; Hepat Mon. 2013 Apr 15;13(4):e6789
  92. Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Bota S, Herkner H, Sporea I, Salzl P, Sirli R, Neghina AM, Peck-Radosavljevic M.; Liver Int. 2013 Sep;33(8):1138-47
  93. Value of acoustic radiation force impulse imaging elastography for non-invasive evaluation of patients with nonalcoholic fatty liver disease. Fierbinteanu Braticevici C, Sporea I, Panaitescu E, Tribus L.; Ultrasound Med Biol. 2013 Nov;39(11):1942-50.
  94. Acoustic radiation force impulse and supersonic shear imaging versus transient elastography for liver fibrosis assessment. Sporea I, Bota S, Jurchis A, Sirli R, Grădinaru-Tascău O, Popescu A, Ratiu I, Szilaski M.; Ultrasound Med Biol. 2013 Nov;39(11):1933-41
  95. Does experience play a role in the ability to perform liver stiffness measurements by means of supersonic shear imaging (SSI)? Grădinaru-Taşcău O, Sporea I, Bota S, Jurchiş A, Popescu A, Popescu M, Şirli R, Szilaski M.; Med Ultrason. 2013 Sep;15(3):180-3
  96. Computer aided diagnosis method for steatosis rating in ultrasound images using random forests. Mihăilescu DM, Gui V, Toma CI, Popescu A, Sporea I; Med Ultrason. 2013 Sep;15(3):184-90
  97. "Standard of care" treatment for chronic viral C hepatitis in 2013 in Romania. Sporea I, Curescu M, Sirli R.; J Gastrointestin Liver Dis. 2013 Sep;22(3):360-1
  98. How many measurements are needed for liver stiffness assessment by 2D-Shear Wave Elastography (2D-SWE) and which value should be used: the mean or median? Sporea I, Grădinaru-Taşcău O, Bota S, Popescu A, Şirli R, Jurchiş A, Popescu M, Dănilă M.; Med Ultrason. 2013 Dec;15(4):268-72
  99. Liver elastography - an update. Sporea I, Gilja OH, Bota S, Şirli R, Popescu A.; Med Ultrason. 2013 Dec;15(4):304-14
  100. Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography - analysis of a cohort of 1,031 subjects. Bota S, Sporea I, Sirli R, Popescu A, Danila M, Jurchis A, Gradinaru-Tascau O.; Eur J Radiol. 2014 Feb;83(2):268-72.
  101. Which are the cut-off values of 2D-Shear Wave Elastography (2D-SWE) liver stiffness measurements predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method? Sporea I, Bota S, Gradinaru-Taşcău O, Sirli R, Popescu A, Jurchiş A.; Eur J Radiol. 2014 Mar;83(3):e118-22.
  102. Contrast-Enhanced Ultrasound (CEUS) For The Evaluation Of Focal Liver Lesions - A Prospective Multicenter Study Of Its Usefulness In Clinical Practice. Sporea I, Badea R, Popescu A, Spârchez Z, Sirli RL, Dănilă M, Săndulescu L, Bota S, Calescu DP, Nedelcu D, Brisc C, Ciobâca L, Gheorghe L, Socaciu M, Martie A, Ioaniţescu S, Tamas A, Streba CT, Iordache M, Simionov I, Jinga M, Anghel A, Cijevschi Prelipcean C, Mihai C, Stanciu SM, Stoicescu D, Dumitru E, Pietrareanu C, Bartos D, Manzat Saplacan R, Pârvulescu I, Vădan R, Smira G, Tuţă L, Săftoiu A.; Ultraschall Med. 2014 Jun;35(3):259-266
  103. Is Contrast Enhanced Ultrasound (CEUS) ready for use in daily practice for evaluation of focal liver lesions? Sporea I, Şirli R.; Med Ultrason. 2014 Mar;16(1):37-40.
  104. Reply to Letter to the Editor re: "Acoustic Radiation Force Impulse and Supersonic Shear Imaging versus Transient Elastography for Liver Fibrosis Assessment". Sporea I, Sirli R.; Ultrasound Med Biol. 2014 Aug;40(8):1918-9
  105. Nonalcoholic fatty liver disease: a frequent condition in type 2 diabetic patients. Sima A, Timar R, Vlad A, Timar B, Rosu M, Dan I, Sirli R, Popescu A, Sporea I.; Wien Klin Wochenschr. 2014 Mar 21.
  106. Characterization of focal liver lesions using contrast enhanced ultrasound as a first line method: a large monocentric experience. Sporea I, Martie A, Bota S, Sirli R, Popescu A, Dănila M.; J Gastrointestin Liver Dis. 2014 Mar;23(1):57-63
  107. Comparison between the M and XL probes for liver fibrosis assessment by transient elastography. Şirli R, Sporea I, Deleanu A, Culcea L, Szilaski M, Popescu A, Dănilă M.; Med Ultrason. 2014 Jun;16(2):119-22.
  108. Romanian national guidelines and practical recommendations on liver elastography. Sporea I, Bota S, Săftoiu A, Şirli R, Gradinăru-Taşcău O, Popescu A, Lupşor Platon M, Fierbinteanu-Braticevici C, Gheonea DI, Săndulescu L, Badea R.; Med Ultrason. 2014 Jun;16(2):123-38
  109. Ultrasound screening for hepatocellular carcinoma in patients with advanced liver fibrosis. An overview. Dănilă M, Sporea I.; Med Ultrason. 2014 Jun;16(2):139-44
  110. Relative performances of FibroTest, Fibroscan, and biopsy for the assessment of the stage of liver fibrosis in patients with chronic hepatitis C: a step toward the truth in the absence of a gold standard. Poynard T, de Ledinghen V, Zarski JP, Stanciu C, Munteanu M, Vergniol J, France J, Trifan A, Le Naour G, Vaillant JC, Ratziu V, Charlotte F; Fibrosis-TAGS group.; J Hepatol. 2012 Mar;56(3):541-8
  111. Tumor angiogenesis in gastric cancer Lazăr D, Raica M, Sporea I, Tăban S, Goldiş A, Cornianu M; Rom J Morphol Embryol 47, 5-13
  112. An unusual "tumor" of the cecum: the inverted appendiceal stump. Tăban S, Dema A, Lazăr D, Sporea I, Lazăr E, Cornianu M.; Rom J Morphol Embryol. 2006;47(2):193-6.
  113. Do the needle type and the operator experience influence liver biopsy specimen quality? I. Sporea, A. Popescu, M. Focşa, G. Becheanu, R. Şirli, M. Cornianu, L. Gheorghe, C. C.Prelipcean, C. Mihai, I. Rogoveanu, L. Săndulescu; Central European Journal of Medicine 2010, Volume 8, Issue 5, pp 669-673