Roxana Lucia Denisa ŞIRLI, MD, PhD


Work experience
  1. 2013 - present Lecturer Department of Gastroenterology and Hepatology "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  2. 1999 - 2013 "Victor Babes" University of Medicine and Pharmacy Eftimie Murgu nr 2, Timişoara (România)
  3. 1995 - 1999 Fellow in Internal Medicine Clinic County Hospital Nr. 1 Timişoara, Bv. Liviu Rebreanu nr. 156, Timişoara (România)
  4. 1992 - 1995 Fellow in Family Medicine Clinic County Hospital Nr. 1 Timişoara, Bv. Liviu Rebreanu nr. 156, Timişoara (România)
  5. 1991 - 1992 General Practitioner, Ianosda, City Hospital Salonta, Jud. Bihor, Romania

Education and training
  1. 2012 Senior Consultant Gastroenterology, "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  2. 2009 PhD Medical Sciences - Gastroenterology "Victor Babes" University of Medicine and Pharmacy, ISCED 6
  3. 2008 Senior Consultant Internal Medicine "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  4. 2005 Specialist Gastroenterology "Victor Babes" University of Medicine and Pharmacy Timişoara (România), ISCED 5
  5. 2000 Specialist Internal Medicine University of Medicine and Pharmacy Timişoara (România), ISCED 5
  6. 1995 Specialist General Practitioner (Family Doctor) University of Medicine and Pharmacy Timişoara (România), ISCED 5
  7. 1990 Medical Doctor Faculty of General Medicine University of Medicine and Pharmacy Timişoara (România), ISCED 5

Scientific activity

       Postgraduate courses
  1. 1999 – Abdominal Ultrasound, UMF Timişoara
  2. 2000 - Endoscopy, UMF Timişoara
  3. 2006 – Endoscopic Ultrasound, UMF Craiova
  4. 2009 – IBISCUS – Imaging School for Contrast-Enhanced Ultrasound, Bucharest
  5. 2009 – International Course of DCE-US with quantification for evaluation in oncology, Institute Gustave Roussy in Villejuif, Paris, France

       Bursaries
  1. Nov. 2000 – 1 month at the Liver Transplant Program of Baylor University Medical Center, Dallas Texas, USA
  2. May 2004 - 1 month at the Centre Hepato-Biliaire de l’Hopital Paul Brusse, Paris, Franta

       Member of:
  1. Romanian Society of Gastronterology and Hepatology
  2. Romanian Society of Digestive Endoscopy
  3. Romanian Society of Ultrasound in Medicine and Biology – since 2010 member in the Board of Directors
  4. European Federation of Societies of Ultrasound in Medicine and Biology
  5. World Federation for Ultrasound in Medicine and Biology

       Publications:
  1. first author of more than 150 scientific papers and co-author of more than 600 scientific papers (a total of 759 papers).
  2. author and co-author of 127 articles, 80 of them indexed in ISI web of science.
  3. co-auhtor of 11 books regarding: Abdominal Ultrasound, Elastography,Social Medicine
  4. co-author of 4 CDs and DVDs of medical imaging (ultrasound)
  5. 18 lectures as an Invited speaker during national and international scientific meetings

       Grants:
  1. Participant in the National CEEX Grant nr. 1/2005: “Molecular basis of colorectal cancer: from prevention to treatment”, as well as to the
  2. Participant in the National CEEX Grant nr. 68/2006 “Optimising the early diagnosis and treatment of upper digestive tract cancer in the context of chromodiagnosis and magnification endoscopy”
  3. Assistant manager and expert: Deployment of a telemedicine system between university gastroenterology centres of Szeged and Timisoara for education and training of professionals. Cross-border cooeration project HURO/1001/140/2.3.1, acronim HURO-TELEMED.

Main published papers
  1. Factors associated with failure of Liver Stiffness measurement using Transient Elastography Şirli R, Sporea I, Deleanu A, Tudora A, Bota S, Popescu A, Dănilă M.; Timisoara Medical Journal 2009: 49 (1); 34-38.
  2. Transient elastographic evaluation of subjects without known hepatic pathology, does age change the liver stiffness? Şirli R, Sporea I, Tudora A, Deleanu A, Popescu A.; J Gastrointestin Liver Dis 2009; 18(1): 57-61
  3. Liver stiffness assessment by means of trasnsient elastography (FibroScan®) in patients with liver cirrhosis – a predictor of portal hypertension? Şirli R, Raţiu I, Deleanu A, Sporea I, Bota S, Dănilă M, Popescu A.; Medical Ultrasonography. 2009: 11 (1);5-10
  4. A Comparative Study of Non-Invasive Methods for Fibrosis Assessment in Chronic HCV Infection Şirli R, Sporea I, Bota S, PopescuA, Cornianu M; Hepatitis Monthly 2010; 10(2): 88-94
  5. Can Acoustic Radiation Force Impulse Elastography (ARFI) predict the complications of liver cirrhosis? Şirli R, Sporea I, Bota S, Ciof O, Popescu A, Danilă M; Rom J Intern Med, 2010, 7(5), 15-20
  6. Comparison of the liver stiffness measurement by transient elastography with the liver biopsy. Sporea I, Şirli R, Deleanu A, Tudora A, Curescu M, Cornianu M, Lazar D.; World J Gastroenterol Nov 2008; 14(42):6513-7
  7. Liver Stiffness Measurement by Transient Elastography in Clinical Practice Sporea I, Şirli R, Deleanu A, Popescu A, Cornianu M.; J Gastrointestin Liver Dis 2008;17(4): 395-399
  8. What to expect from FibroScan (transient elastography) for the evaluation of chronic hepatopathies Sporea I, Şirli R.; Medical Ultrasonography 2008; 10 (1): 7-12
  9. Transient elastography in the evaluation of patients with nonalcoholic steatohepatitis Dan I, Sporea I, Sirli R, Nicolita D; Medical Ultrasonography. 2009: 11 (2);11-14
  10. Feasibility, accuracy and reproducibility of transient elastography Deleanu A, Şirli R, Popescu A, Sporea I; Medical Ultrasonography. 2009: 11 (4);31-35
  11. Acoustic Radiation Force Impulse (ARFI) – a new modality for the evaluation of liver fibrosis Sporea I, Şirli R, Popescu A, Danilă M; Medical Ultrasonography 2010, Vol. 12, no. 1, 26-31
  12. Spleen assessment by Acoustic radiation Force Impulse Elastography (ARFI) for prediction of liver cirrhosis and portal hypertension Bota S, Sporea I, Sirli R, Popescu A, Danila M, sendroiu M, Focsa M; Medical Ultrasonography 2010; 12 (3): 213-215
  13. What Did We Learn from the First 3,459 Cases of Liver Stiffness Measurement by Transient Elastography (FibroScan(R))? Sporea I, Sirli RL, Deleanu A, Iulia R, Tudora A, Dan I, Popescu A.; Ultraschall Med. 2011 Feb;32(1):40-45. [Epub ahead of print 2010 Jul 5]
  14. Acoustic Radiation Force Impulse Elastography as Compared to Transient Elastography and Liver Biopsy in Patients with Chronic Hepatopathies. Sporea I, Sirli RL, Deleanu A, Popescu A, Focsa M, Danila M, Tudora A.; Ultraschall Med. 2011;32 Suppl 1:S46-52 . [Epub ahead of print 2010 Jul 5]
  15. Liver stiffness measurements in patients with HBV vs HCV chronic hepatitis: a comparative study. Sporea I, Sirli R, Deleanu A, Tudora A, Popescu A, Curescu M, Bota S.; World J Gastroenterol. 2010 Oct 14;16(38):4832-7.
  16. Thyroid Stiffness Assessment by Acoustic Radiation Force Impulse Elastography (ARFI). Sporea I, Vlad M, Bota S, Sirli RL, Popescu A, Danila M, Sendroiu M, Zosin I.; Ultraschall Med. 2011 Jun;32(3):281-5, 2011 Feb 14. [Epub ahead of print]
  17. The mean values of liver stiffness assessed by Acoustic Radiation Force Impulse elastography in normal subjects. Popescu A, Sporea I, Sirli R, Bota S, Focsa M, Danila M, Nicolita D, Martie A, Sendroiu M, Juchis A.; Med Ultrason. 2011 Mar;13(1):33-7.
  18. Value of transient elastography for the prediction of variceal bleeding. Sporea I, Raţiu I, Sirli R, Popescu A, Bota S.; World J Gastroenterol. 2011 May 7;17(17):2206-10.
  19. Factors that influence the correlation of Acoustic Radiation Force Impulse (ARFI), elastography with liver fibrosis. Bota S, Sporea I, Sirli R, Popescu A, Danila M, Sendroiu M.; Med Ultrason. 2011 Jun;13(2):135-40.
  20. Is ARFI elastography reliable for predicting fibrosis severity in chronic HCV hepatitis? Sporea I, Sirli R, Bota S, Fierbinţeanu-Braticevici C, Petrişor A, Badea R, Lupşor M, Popescu A, Dănilă M.; World J Radiol. 2011 Jul 28;3(7):188-93.
  21. How efficient is acoustic radiation force impulse elastography for the evaluation of liver stiffness? Sporea I, Badea R, Sirli R, Lupsor M, Popescu A, Danila M, et al.; Hepat Mon. 2011;11(7):532-8.
  22. A new scoring system for prediction of fibrosis in chronic hepatitis C. Bota S, Sirli R, Sporea I, Focsa M, Popescu A, Danila M, et al.; Hepat Mon. 2011;11(7):548-5.
  23. Assessment of noninvasive liver stiffness in inactive HBsAg carriers by transient elastography. Sporea I, Nicolita D, Sirli R, Deleanu A, Tudora A, Bota S.; Hep Mon. 2011;11(3):182-185.
  24. The influence of liver residual mass on the values of Acoustic Radiation Force Impulse Elastography (ARFI) in cirrhotic patients. Bota S, Sporea I, Sirli R, Popescu A, Dănilă M, Sendroiu M.; Med Ultrason. 2011 Sep;13(3):195-9.
  25. Is it better to use two elastographic methods for liver fibrosis assessment? Sporea I, Şirli R, Popescu A, Bota S, Badea R, Lupşor M, Focşa M, Dănilă M; World J Gastroenterol 2011; 17(33): 3824-3829
  26. Response to standard of care antiviral treatment in patients with HCV liver cirrhosis - a systematic review. Bota S, Sporea I, Popescu A, Sirli R, Neghina AM, Danila M, Strain M.; J Gastrointestin Liver Dis. 2011 Sep;20(3):293-8
  27. Value of acoustic radiation force impulse elastography for the assessment of ascites syndrome Bota S, Sporea I, Şirli R, Popescu A, Dănilă M, Şendroiu M.; World J Radiol 2011. 3(8):205 -209.
  28. The Correlation of Il28B Genotype With Sustained Virologic Response In Romanian patients With Chronic Hepatitis C. Sporea I, Popescu A, Curescu M, Sirli R, Dan I, Goldis A, Gradinaru O, Ardelean M, Danila M, Bota S, Deleanu A.; Hepat Mon. 2011 Dec;11(12):975-9. Epub 2011 Dec 20.
  29. Intra- and Interoperator Reproducibility of Acoustic Radiation Force Impulse (ARFI) Elastography-Preliminary Results. Bota S, Sporea I, Sirli R, Popescu A, Danila M, Costachescu D.; Ultrasound Med Biol. 2012. Jul;38(7):1103-8
  30. Comparative Study Concerning the Value of Acoustic Radiation Force Impulse Elastography (ARFI) in Comparison with Transient Elastography (TE) for the Assessment of Liver Fibrosis in Patients with Chronic Hepatitis B and C. Sporea I, Șirli R, Bota S, Popescu A, Sendroiu M, Jurchis A.; Ultrasound Med Biol. 2012;38(8):1310-6
  31. Can ARFI elastography predict the presence of significant esophageal varices in newly diagnosed cirrhotic patients? Bota S, Sporea I, Șirli R, Focsa M, Popescu A, Danila M, Strain M.; Ann Hepatol. 2012 Jul;11(4):519-25.
  32. Hepatic Elastography for the Assessment of Liver Fibrosis - Present and Future. Sporea I, Șirli R.; Ultraschall Med. 2012 Dec;33(6):550-558.
  33. Does the size of the needle influence the number of portal tracts obtained through percutaneous liver biopsy? Sporea I, Gherhardt D, Popescu A, Șirli R, Cornianu M, Herman D, Bota S.; Ann Hepatol. 2012 Sep;11(5):691-5
  34. Acoustic Radiation Force Impulse Elastography for fibrosis evaluation in patients with chronic hepatitis C: An international multicenter study. Sporea I, Bota S, Peck-Radosavljevic M, Șirli R, Tanaka H, Iijima H, Badea R, Lupsor M, Fierbinteanu-Braticevici C, Petrisor A, Saito H, Ebinuma H, Friedrich-Rust M, Sarrazin C, Takahashi H, Ono N, Piscaglia F, Borghi A, D'Onofrio M, Gallotti A, Ferlitsch A, Popescu A, Danila M.; Eur J Radiol. 2012 Dec;81(12):4112-8 .
  35. Factors Which Influence the Accuracy of Acoustic Radiation Force Impulse (ARFI) Elastography for the Diagnosis of Liver Fibrosis in Patients With Chronic Hepatitis C. Bota S, Sporea I, Șirli R, Popescu A, Jurchis A.; Ultrasound Med Biol. 2013 Mar;39(3):407-12.
  36. Quiz. Cystic tumor of the Liver. Șirli R, Sporea I, Jurchis A.; Med Ultrason. 2012 Mar;14(1):78-9
  37. ARFI elastography for the evaluation of diffuse thyroid gland pathology: Preliminary results. Sporea I, Șirli R, Bota S, Vlad M, Popescu A, Zosin I.; World J Radiol. 2012 Apr 28;4(4):174-8
  38. Contrast Enhanced Ultrasound for the evaluation of focal liver lesions in daily practice. A multicentre study. Sporea I, Badea R, Martie A, Dumitru E, Ioanitescu S, Șirli R, Socaciu M, Popescu A, Dănilă M, Voiculescu M.; Med Ultrason. 2012 Jun;14(2):95-100
  39. Liver elastography for the diagnosis of portal hypertension in patients with liver cirrhosis. Șirli R, Sporea I, Bota S, Ratiu I.; Med Ultrason. 2012 Sep;14(3):225-30
  40. Contrast-enhanced ultrasound assessment of focal liver lesions with SonoVue® Sporea I, Șirli R; Imaging in Medicine. 2012; 4:(2): 163-170
  41. The Contribution of Contrast Enhanced Ultrasound for the characterization of benign liver lesions in clinical practice - a monocentric experience. Martie A, Bota S, Sporea I, Șirli R, Popescu A, Danila M.; Med Ultrason. 2012 Dec;14(4):283-7
  42. Predictive factors for severe evolution in acute pancreatitis and a new score for predicting a severe outcome Bota S, Sporea I, Sirli R, Popescu A, Strain M, Focsa M, Danila M, Chisevescu D; Ann Gastroenterol 2013; 26 (2): 1-7
  43. Factors which influence the accuracy of acoustic radiation force impulse (ARFI) elastography for the diagnosis of liver fibrosis in patients with chronic hepatitis C. Bota S, Sporea I, Sirli R, Popescu A, Jurchis A.; Ultrasound Med Biol. 2013 Mar;39(3):407-12.
  44. The influence of food intake on liver stiffness values assessed by acoustic radiation force impulse elastography-preliminary results. Popescu A, Bota S, Sporea I, Sirli R, Danila M, Racean S, Suseanu D, Gradinaru O, Ivascu Siegfried C.; Ultrasound Med Biol. 2013 Apr;39(4):579-84
  45. The influence of aminotransferase levels on liver stiffness assessed by Acoustic Radiation Force Impulse Elastography: A retrospective multicentre study. Bota S, Sporea I, Peck-Radosavljevic M, Sirli R, Tanaka H, Iijima H, Saito H, Ebinuma H, Lupsor M, Badea R, Fierbinteanu-Braticevici C, Petrisor A, Friedrich-Rust M, Sarrazin C, Takahashi H, Ono N, Piscaglia F, Marinelli S, D'Onofrio M, Gallotti A, Salzl P, Popescu A, Danila M.; Dig Liver Dis. 2013 Mar 16. doi:pii: S1590-8658(13)00061-3. 10.1016/j.dld.2013.02.008.
  46. Role of Interleukin-28B Polymorphism as a Predictor of Sustained Virological Response in Patients with Chronic Hepatitis C Treated with Triple Therapy: A Systematic Review and Meta-Analysis. Bota S, Sporea I, Sirli R, Neghină AM, Popescu A, Străin M.; Clin Drug Investig. 2013 May;33(5):325-31
  47. Severe adverse events during antiviral therapy in hepatitis C virus cirrhotic patients: A systematic review. Bota S, Sporea I, Sirli R, Popescu A, Neghină AM, Dănilă M, Străin M.; World J Hepatol. 2013 Mar 27;5(3):120-6
  48. Factors influencing reliability of liver stiffness measurements using transient elastography (M-probe)-Monocentric experience. Sirli R, Sporea I, Bota S, Jurchiş A.; Eur J Radiol. 2013 Apr 3. doi:pii: S0720-048X(13)00126-5. 10.1016/j.ejrad.2013.03.002.
  49. Can Transient Elastography be a reliable method for assessing liver fibrosis in non alcoholic steatohepatitis (NASH)? Sporea I, Jurchis A, Sirli R, Bota S, Sendroiu M.; Med Ultrason. 2013 Jun;15(2):106-10.
  50. Are different cut-off values of liver stiffness assessed by transient elastography according to the etiology of liver cirrhosis for predicting significant esophageal varices? Sporea I, Ratiu I, Bota S, Sirli R, Jurchis A.; Med Ultrason. 2013 Jun;15(2):111-5
  51. Liver stiffness measurements by means of supersonic shear imaging in patients without known liver pathology. Sirli R, Bota S, Sporea I, Jurchis A, Popescu A, Gradinaru-Tascău O, Szilaski M.; Ultrasound Med Biol. 2013 Aug;39(8):1362-7
  52. Meta-analysis: ARFI elastography versus transient elastography for the evaluation of liver fibrosis. Bota S, Herkner H, Sporea I, Salzl P, Sirli R, Neghina AM, Peck-Radosavljevic M.; Liver Int. 2013 Sep;33(8):1138-47
  53. Acoustic Radiation Force Impulse and Supersonic Shear Imaging Versus Transient Elastography for Liver Fibrosis Assessment. Sporea I, Bota S, Jurchis A, Sirli R, Grădinaru-Tascău O, Popescu A, Ratiu I, Szilaski M.; Ultrasound Med Biol. 2013 Aug 8. doi:pii: S0301-5629(13)00754-0.
  54. Does experience play a role in the ability to perform liver stiffness measurements by means of supersonic shear imaging (SSI)? Gradinaru-Tascau O, Sporea I, Bota S, Jurchis A, Popescu A, Popescu M, Sirli R, Szilaski M.; Med Ultrason. 2013 Sep;15(3):180-3.
  55. "Standard of care" treatment for chronic viral C hepatitis in 2013 in Romania. Sporea I, Curescu M, Sirli R.; J Gastrointestin Liver Dis. 2013 Sep;22(3):360-1
  56. How many measurements are needed for liver stiffness assessment by 2D-Shear Wave Elastography (2D-SWE) and which value should be used: the mean or median? Sporea I, Grădinaru-Taşcău O, Bota S, Popescu A, Şirli R, Jurchiş A, Popescu M, Dănilă M.; Med Ultrason. 2013 Dec;15(4):268-72
  57. Liver elastography - an update. Sporea I, Gilja OH, Bota S, Şirli R, Popescu A.; Med Ultrason. 2013 Dec;15(4):304-14
  58. Factors associated with the impossibility to obtain reliable liver stiffness measurements by means of Acoustic Radiation Force Impulse (ARFI) elastography--analysis of a cohort of 1,031 subjects. Bota S, Sporea I, Sirli R, Popescu A, Danila M, Jurchis A, Gradinaru-Tascau O.; Eur J Radiol. 2014 Feb;83(2):268-72.
  59. Which are the cut-off values of 2D-Shear Wave Elastography (2D-SWE) liver stiffness measurements predicting different stages of liver fibrosis, considering Transient Elastography (TE) as the reference method? Sporea I, Bota S, Gradinaru-Taşcău O, Sirli R, Popescu A, Jurchiş A.; Eur J Radiol. 2014 Mar;83(3):e118-22.
  60. Contrast-Enhanced Ultrasound (CEUS) For The Evaluation Of Focal Liver Lesions - A Prospective Multicenter Study Of Its Usefulness In Clinical Practice. Sporea I, Badea R, Popescu A, Spârchez Z, Sirli RL, Dănilă M, Săndulescu L, Bota S, Calescu DP, Nedelcu D, Brisc C, Ciobâca L, Gheorghe L, Socaciu M, Martie A, Ioaniţescu S, Tamas A, Streba CT, Iordache M, Simionov I, Jinga M, Anghel A, Cijevschi Prelipcean C, Mihai C, Stanciu SM, Stoicescu D, Dumitru E, Pietrareanu C, Bartos D, Manzat Saplacan R, Pârvulescu I, Vădan R, Smira G, Tuţă L, Săftoiu A.; Ultraschall Med. 2014 Jun;35(3):259-266
  61. Is Contrast Enhanced Ultrasound (CEUS) ready for use in daily practice for evaluation of focal liver lesions? Sporea I, Şirli R.; Med Ultrason. 2014 Mar;16(1):37-40.
  62. Reply to Letter to the Editor re: "Acoustic Radiation Force Impulse and Supersonic Shear Imaging versus Transient Elastography for Liver Fibrosis Assessment". Sporea I, Sirli R.; Ultrasound Med Biol. 2014 Aug;40(8):1918-9
  63. Nonalcoholic fatty liver disease: a frequent condition in type 2 diabetic patients. Sima A, Timar R, Vlad A, Timar B, Rosu M, Dan I, Sirli R, Popescu A, Sporea I.; Wien Klin Wochenschr. 2014 Mar 21. [Epub ahead of print
  64. Characterization of focal liver lesions using contrast enhanced ultrasound as a first line method: a large monocentric experience. Sporea I, Martie A, Bota S, Sirli R, Popescu A, Dănila M.; J Gastrointestin Liver Dis. 2014 Mar;23(1):57-63
  65. Comparison between the M and XL probes for liver fibrosis assessment by transient elastography. Şirli R, Sporea I, Deleanu A, Culcea L, Szilaski M, Popescu A, Dănilă M.; Med Ultrason. 2014 Jun;16(2):119-22.
  66. Romanian national guidelines and practical recommendations on liver elastography. Sporea I, Bota S, Săftoiu A, Şirli R, Gradinăru-Taşcău O, Popescu A, Lupşor Platon M, Fierbinteanu-Braticevici C, Gheonea DI, Săndulescu L, Badea R.; Med Ultrason. 2014 Jun;16(2):123-38
  67. Do the needle type and the operator experience influence liver biopsy specimen quality? I. Sporea, A. Popescu, M. Focşa, G. Becheanu, R. Şirli, M. Cornianu, L. Gheorghe, C. C.Prelipcean, C. Mihai, I. Rogoveanu, L. Săndulescu; Central European Journal of Medicine 2014, Volume 8, Issue 5, pp 669-673